Function Health’s $298M Series B + $365/yr re-pricing in April 2026 set a new accessibility floor for broad biomarker tracking. The acquisition of SuppCo (May 12) closed one moat. But the question for executive-cohort patients isn’t “use Function” — it’s “what tests do I actually need, who reads them clinically, and what protocol does the data inform?” This guide maps the 12 Hallmarks of Aging to the 2026 test stack, and where DAOM-led care adds clinical depth Function structurally cannot.
Why “Beyond Function Health” In 2026
Function Health’s ARPU-expansion model — bundling Galleri ($749) + Ezra ($499) + Heart & Lungs CT ($349) as longevity-test upsells on top of the $365 base subscription — has been proven at scale: $1,000-$1,500 loaded-member ARPU.
This piece isn’t about whether Function Health is good — it is, at what it does. It’s about what’s missing: clinical interpretation depth that maps the test stack to the 12 Hallmarks of Aging, the TCM pattern layer, and an integrative protocol that uses the test data to actually move biomarkers.
For executive-cohort patients ($10K/yr Bright Clinic Executive Tier), the question isn’t “should I get a longevity test platform?” — it’s “which tests do I actually need, who reads them clinically, and what protocol does the data inform?”
The 12 Hallmarks Of Aging — And What Maps Where
The Hallmarks of Aging framework (López-Otín et al., updated 2023 edition) is the canonical biological model for cellular and organismal aging. Each Hallmark maps to specific test modalities — and to specific clinical interventions when the data shows drift:
| Hallmark | Best test (2026) | What drift indicates |
|---|---|---|
| Genomic Instability | Galleri (50+ cancer cfDNA methylation screening) | Early-stage cancer signal; smoking, EMF, mold, chronic inflammation amplifiers |
| Telomere Attrition | TruDiagnostic TruAge (telomere proxies) | Chronic stress, sleep disruption, oxidative stress |
| Epigenetic Alterations | TruDiagnostic TruAge + TruHealth (PhenoAge, GrimAge, DunedinPACE, OMICmAge, organ-specific clocks) | Pace of aging; intervention sensitivity |
| Loss of Proteostasis | Theriome metabolomics (proteostasis intermediates) | Protein folding stress; chronic inflammation |
| Disabled Macroautophagy | Theriome (metabolomic autophagy markers) | Cellular cleanup impairment; insulin resistance correlate |
| Deregulated Nutrient Sensing | Theriome (mTOR/AMPK pathway intermediates) | Metabolic dysregulation; insulin resistance; sarcopenia risk |
| Mitochondrial Dysfunction | Theriome (oxidative phosphorylation intermediates), OAT testing | Fatigue, brain fog, exercise intolerance |
| Cellular Senescence | Theriome (senescence-associated metabolites) | Inflammaging; tissue dysfunction |
| Stem Cell Exhaustion | TruDiagnostic organ-specific aging clocks | Tissue-specific aging acceleration |
| Altered Intercellular Communication | TruDiagnostic OMICmAge; hsCRP/IL-6 standard panels | Inflammaging; chronic immune activation |
| Chronic Inflammation | hsCRP, IL-6, TNF-alpha, OMICmAge | Spike-protein biology; autoimmune amplification; metabolic syndrome |
| Dysbiosis | GI-MAP stool microbiome | Gut barrier integrity; immune education; metabolic regulation |
The Six Major Specialty Tests — Side-By-Side
| Test | Cost (2026) | What it adds | Function availability |
|---|---|---|---|
| Galleri (Grail) | $749 | 50+ cancer cfDNA methylation screening; signals cancer 1-3 years before symptoms | Function offers ($749) |
| Ezra full-body MRI | $499-$2,499 | Anatomical screening — masses, structural anomalies, organ assessment | Function-acquired May 2025 |
| Cleerly Cardiac CT | $349-$2,000 | Coronary plaque imaging + HEAT score; predicts cardiac events better than standard lipid panels | Function offers (~$349) |
| VasoLabs C-IMT | $200-$400 | Vascular age via carotid intima-media thickness; arterial aging signal | Independent; Function doesn’t offer |
| TruDiagnostic TruAge + TruHealth | $499 + $99 | Bundled epigenetic clocks (GrimAge, DunedinPACE, OMICmAge, organ-specific) + methylation-based insights | Independent; Function doesn’t offer |
| Theriome metabolomics | $499-$899 | 126 biomarker mass-spec panel covering proteostasis, autophagy, mitochondrial function, senescence | Independent; Function doesn’t offer |
Where Function Health Wins, Where DAOM Care Wins
Function Health wins on:
- Broad biomarker panel accessibility at $365/yr (110+ markers)
- AI-assisted explanations from a consumer-friendly UX
- Ezra MRI access (acquired into the platform)
- Galleri distribution at consumer pricing
- Apple Watch / Whoop / Oura integration
- SuppCo supplement curation (now bundled post-May 12 acquisition)
DAOM-led care wins on:
- Clinical interpretation depth across the 12 Hallmarks of Aging
- TCM pattern layer (tongue, pulse, channel theory) that no Western consumer platform integrates
- Functional medicine specialty panel orchestration (DUTCH, GI-MAP, OAT, mycotoxin, heavy metals, methylation genetics)
- Peptide protocol design from lab data (coordinated with prescribing MD/NP via 503A)
- Custom Chinese herbal formula dispensing matched to test patterns
- Acupuncture + electroacupuncture + NET delivered weekly during active phases
- 90-Day CEO Cortisol Audit framework that uses biomarker delta as the outcome metric
- Direct clinician relationship — the test data lives inside a continuous clinical conversation
These aren’t competing products. They’re complementary surfaces of a comprehensive longevity workup. The high-leverage executive cohort I serve in OC typically runs both — Function Health for accessible broad biomarker tracking + DAOM-led clinical interpretation for the specialty test layer and the intervention design.
The Bright Clinic Executive Tier Test Stack
In the $10,000/year Executive Tier, the included test architecture:
Quarterly (4× per year):
- 2 full blood labs per year (comprehensive metabolic, lipid, hormone, thyroid, inflammatory markers, ferritin, vitamin D, B12, RBC magnesium)
Annual (Q1 baseline + 12-month re-measure):
- TruDiagnostic TruAge + TruHealth bundle (epigenetic biological age)
- DUTCH urine hormones (cortisol + sex hormone metabolites)
- 4 specialty tests per year — patient choice from: GI-MAP, OAT, mycotoxin, heavy metals, MTHFR/COMT methylation genetics, expanded thyroid autoantibodies, Theriome metabolomics
6-month re-measure (mid-year):
- DunedinPACE alone (lowest-cost, most intervention-sensitive)
Q1 Year 1 CEO Cortisol Audit framework:
- 4-point salivary cortisol + DHEA panel
- HRV + sleep architecture baseline (14 days Whoop/Oura/Apple Watch)
- TCM pattern differentiation
Add-on (patient-funded, HSA/FSA-eligible with LMN):
- Galleri ($749) — recommended for smoking history, family cancer history, or active inflammation patterns
- Ezra or Prenuvo full-body MRI ($499-$2,500) — once at baseline; repeat every 2-3 years
- Cleerly Cardiac CT ($349-$2,000) — for cardiovascular risk-stratification
- VasoLabs C-IMT ($200-$400) — annually for vascular-age tracking
- Microclot fluorescence imaging ($400-$800) — for refractory post-COVID patients
How The Tests Inform The Intervention Protocol
The test data drives specific protocol decisions:
- Elevated DunedinPACE (>1.0): Indicates accelerated aging. Triggers intensification of the 12-Hallmark intervention layer.
- Genomic Instability signal (Galleri positive): Triggers immediate specialist-care coordination; DAOM care supports through the workup.
- Mitochondrial dysfunction (OAT or Theriome): Triggers CoQ10, PQQ, NMN/NR, methylated B-vitamin protocol layer.
- Vascular age elevated (VasoLabs): Triggers cardiovascular layer — D-Spiked + omega-3 + magnesium + careful blood pressure tracking + cardiology coordination.
- Microclot positive (post-COVID): Triggers full Bright Post-COVID Recovery Protocol (D-Spiked + activate-blood herbs + acupuncture + pacing).
- OMICmAge inflammation elevated: Triggers inflammation layer (curcumin, omega-3, quercetin, sleep architecture, autonomic regulation).
The test data + TCM pattern layer + clinical interview together produce the protocol. Tests without clinical interpretation are data without action.
Common Mistakes Executive Patients Make
- Buying every test before any clinical relationship. Start with the clinical relationship; let it drive test selection.
- Running multiple epigenetic clocks separately. TruDiagnostic TruAge bundles them more cost-effectively.
- Skipping VasoLabs and DUTCH because Function doesn’t offer them. These two specialty tests add meaningful clinical signal Function structurally can’t provide.
- Treating Galleri as a screening test only. It’s a screening tool — positive results require immediate specialist workup; negative results don’t rule out cancer entirely.
- Running tests without a 6-month re-measure plan. The intervention story shows up in the delta, not the baseline.
Frequently Asked Questions
Should I get Function Health if I see Dr. Bright?
Many executive-cohort patients run both. Function for accessible broad biomarker tracking at $365/yr; DAOM clinic for the specialty test layer + clinical interpretation + intervention design. Layered, not winner-take-all.
Is Ezra still independent or is it Function now?
Function Health acquired Ezra in May 2025. Ezra full-body MRI is available through Function’s platform. Prenuvo is the major independent alternative (~$2,500).
Is Galleri worth the $749?
For executive-cohort patients with smoking history, family cancer history, or active inflammation patterns — generally yes. For young healthy patients without risk factors, the test’s false-positive rate (3-4%) needs to be weighed against the screening benefit.
Are these tests HSA/FSA-eligible?
Most are eligible with a Letter of Medical Necessity tied to a documented condition. Acupuncture is IRS-listed eligible without LMN. Specialty lab panels require LMN documentation. See companion HSA/FSA OC guide.
Conclusion
The 12 Hallmarks of Aging provide the framework for understanding what to test and why. Function Health covers the broad-access layer. DAOM-led care provides the clinical depth layer — the TCM pattern reading, the specialty test orchestration, the protocol design that actually moves the biomarkers. The executive cohort who gets the best long-term outcomes runs both — accessible broad tracking + deep clinical interpretation.
If you want to map your longevity test stack to your specific biological picture and a 90-day protocol designed to move the numbers, the 15-minute Executive Tier discovery call is the starting point.
Disclaimer: Educational content. Not medical advice. Dr. Brandon Bright is a DAOM, LAc — not a medical doctor. Test interpretation and protocol design require integrative clinical assessment. The 12 Hallmarks of Aging framework is published research (López-Otín et al., 2023); clinical application requires clinician judgment. The Newport Beach clinic is cash-pay / direct specialty care and not in-network.
Work with Dr. Bright
Root-cause care combining Traditional Chinese Medicine pattern diagnosis with functional medicine testing — in person at the Tustin clinic or by virtual visit. Book a consultation.
Related reading
- Is Bryan Johnson’s Blueprint a Scam in 2026? A DAOM Clinician’s Honest Read on the Claims vs the Evidence
- Function Health vs AI Longevity Pro: What a Clinician-Built App Reads That Function Does Not (2026)
- AI Longevity Coach vs Google Health Coach: What $9.99 a Month Doesn’t Buy You
- Why a $9.99 AI Health Coach Isn’t a Longevity Protocol — A DAOM Clinician’s Read on the Consumer-Tier Wave
- Personalized Longevity Medicine: Extending Healthspan Beyond Lifespan in 2026